Approximately half of individuals with rheumatoid arthritis experience profound fatigue and pain, even after their joint disease activity has been improved by medications. The symptoms suggest that the inflammation caused by rheumatoid arthritis might also impact the brain and nervous system. Jarred W. Younger, PhD, associate professor at the University of Alabama at Birmingham, is studying brain thermometry, a noninvasive method that could detect and measure the neuroinflammation caused by rheumatoid arthritis. His technique could help doctors better understand the cause of the pain and fatigue experienced daily by people like Elizabeth.